Police evacuated buildings in King Street and closed two roads following reports of a suspicious package yesterday afternoon.
The bomb disposal team have arrived in Luton town centre and are using a robot.
King Street was closed at Stuart Street and George Street, with some businesses in George Street also opting to evacuate.
A spokesperson for Bedfordshire Police said: “We were called today (Tuesday) at around 2.30pm to reports of a suspicious package in King Street.
“Explosive Ordnance Disposal specialists have been alerted and the road has been closed at Stuart Street and George Street as a precaution while investigations take place.”
One of the buildings to be evacuated was Age Concern Luton, where director Colette McKeaveney said: “A volunteer on reception had been told that we had to evacuate the building.
“Somebody went down to check and the PCSO said you have to get out quickly. We noticed that there were various police officers and PCSOs along the street evacuating the buildings. We had to leave the building via the bottom of the street and there were sniffer dogs on the street.
“We were not told anything, just to get out and get out quickly. The police were very calm and competent and it was very quick.”