Plans are afoot to transform the empty Noah shop in High Town Road into a Morrisons convenience store.
An application was submitted to Luton Borough Council for the site at 11-15 High Town Road to be converted for use by the supermarket chain.
The 447sq ft ground floor has been earmarked for retail, office and workshop space, with no plans for the floors above.
Neighbours have until January 13 to send their responses to the council planning department, with official consultations to be completed by January 6.
An overall decision on the proposal is expected to be reached by February.